2018

Ranad Shaheen, Sateesh Maddirevula, Nour Ewida, Saud Alsahli, Ghada M H Abdel-Salam, Maha S. Zaki, Saeed Al Tala, Amal Alhashem, Ameen Softah, Mohammed Al-Owain, Anas M Alazami, Basma Abadel, Nisha Patel, Tarfa Al-Sheddi, Rana Alomar, Eman Alobeid, Niema Ibrahim, Mais Hashem, Firdous Abdulwahab, Muddathir Hamad, Brahim Tabarki, Ali H. Alwadei, Fahad Alhazzani, Fahad A Bashiri, Amal Kentab, Serdar Şahintürk, Elliott Sherr, Brieana Fregeau, Samira Sogati, Saad Ali M. Alshahwan, Salwa Alkhalifi, Zainab Alhumaidi, Samia Temtamy, Mona Aglan, Ghada Otaify, Katta M Girisha, Maha Tulbah, Mohammed Zain Seidahmed, Mustafa A Salih, Mohamed Abouelhoda, Afaque A. Momin, Muna Al Saffar, Jennifer N. Partlow, Stefan T. Arold, Eissa Faqeih, Christopher Walsh, Fowzan S Alkuraya

Cancers

 ​   

Umar S. Hameed, Oana Sanislav, Sui T. Lay, Sarah J. Annesley, Chacko Jobichen, Paul R. Fisher, Kunchithapadam Swaminathan, Stefan T. Arold​ 

Ophtalmic Genetics

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EMBO Reports

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Albert Giralt, Benoit de Pins; Carmen Cifuentes-Diaz, Laura  López-Molina; Amel Thamila Farah; Marion Tible, Vincent  Deramecourt, Stefan T. Arold, Silvia Gines, Jacques Hugon, Jean-Antoine Girault 

BMC Genomics ​

  

Michael S Nahorski, Sateesh Madirevula, Ryosuke Ishimura, Saud Alsahli, Angela Brady, Tsunehiro Mizushima, Francisco J. Guzman Vega, Miki Obata, Yoshinobu Ichimura, Hessa S Alsaif, Shams Anazi, Niema Ibrahim, Firdous Abdulwahab, Mais Hashem, Dorota Monies, Mohamed Abouelhoda, Brian F Meyer, Majid Alfadhel, Wafa Eyaid, Markus Zweier, Katharina Steindl, Anita Rauch, Stefan T. Arold, C Geoffrey Woods, Masaaki Komatsu, Fowzan S Alkuraya 

Am. J. Med. Gen. Part A ​

Identification and Experimental Characterization of an Extremophilic Brine Pool Alcohol Dehydrogenase from Single Amplified Genomes.

Grötzinger SW, Karan R, Strillinger E, Bader S, Frank A, Al Rowaihi IS, Akal A, Wackerow W, Archer JA, Rueping M, Weuster-Botz D, Groll M, Eppinger J, Arold ST

ACS Chemical Biology

M. Handberg-Thorsager, J. Gutierrez-Mazariegos, S. T. Arold, E. Kumar Nadendla, P. Y. Bertucci, P. Tomançak, K. Pierzchalski, J. W. Jones, R. Albalat, M. A. Kane, W. Bourguet, V. Laudet, D. Arendt, M. Schubert

Science Advances

Ph​osphorylation of threonine residues on Shc promotes ligand binding and mediates crosstalk between MAPK and Akt pathways in breast cancer cells.

Suen KM, Lin CC, George R, Poncet-Montange G, Biter AB, Ahmed Z, Arold ST, Ladbury JE

Int. J. of Biochemistry & Cell Biology

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2017

Mutations of PTPN23 in developmental and epileptic encephalopathy.

Sowada N, Hashem MO, Yilmaz R, Hamad M, Kakar N, Thiele H, Arold ST, Bode H, Alkuraya FS, Borck G

Human Genetics

Methyl phenlactonoates are efficient strigolactone analogs with simple structure.

Muhammad Jamil, Boubacar A. Kountche, Imran Haider, Xiujie Guo, Valentine O. Ntui, Kunpeng Jia, Shawkat Ali, Umar S. Hameed, Hidemitsu Nakamura, Ying Lyu, Jiang Kai, Kei Hirabayashi, Masaru Tanokura, Stefan T. Arold, Tadao Asami, and Salim Al-Babili

Journal of Experimental Botany

Recessive VARS2 mutation underlies a novel syndrome with epilepsy, mental retardation, short stature, growth hormone deficiency, and hypogonadism.

Abdulaziz Al-Semari, Banan Al-Younes, Ewa Goljian, Dyala Jaroudi, Faisal S BinHumaid, Brian F Meyer, Stefan T Arold, Dorota M Monies

Human Genomics

Expanding the genetic heterogeneity of intellectual disability.

Shams Anazi; Sateesh Maddirevula; Vincenzo Salpietro; Yasmine Asi; Saud Alsahli; Amal Alhashem; Hanan E Shamseldin; Fatema AlZahrani; Nisha Patel; Niema Ibrahim; Firdous Abdulawahab; Mais Hashem; Nadia Alhashmi; Fathiya Al Murshedi; Adila Al Kindy; Ahmad Alshaer; Ahmed Rumayyan; Saeed Al Tala; Wesam Kurdi; Abdulaziz Alsaman; Ali Alasmari; Selina Banu; Tipu Sultan; Mohammed Saleh; Hisham Alkuraya; Mustafa Salih; Hesham Aldhalaan; Tawfeg Ben-Omran; Fatima Al Musafri; Rehab Ali; Jehan Suleiman; Brahim Tabarki; Ayman El-Hattab; Caleb Bupp; Majid Alfadhel; Nada Al-Tassan; Dorota Monies; Stefan T. Arold; Mohamed Abouelhoda; Tammaryn Lashley; Henry Houlden; Eissa Faqeih; Fowzan S. Alkuraya 

Human Genetics

A Children's Oncology Group and TARGET initiative exploring the genetic landscape of Wilms tumor.

Samantha Gadd, Vicki Huff,  Amy L. Walz, Ariadne H.A.G. Ooms,  Amy E. Armstrong, Daniela S. Gerhard, Malcolm A. Smith, Jaime M. Guidry Auvil,  Daoud Meerzaman, Qing-Rong Chen, Chih Hao Hsu, Chunhua Yan, Cu Nguyen, Ying Hu,  Leandro C. Hermida, Tanja Davidsen,  Patee Gesuwan, Yussanne Ma,  Zusheng Zong, Andrew J. Mungall, Richard A. Moore, Marco A. Marra, Jeffrey S. Dome, Charles G. Mullighan, Jing Ma, David A. Wheeler, Oliver A. Hampton, Nicole Ross, Julie M. Gastier-Foster, Stefan T. Arold, Elizabeth J. Perlman 

Nature Genetics

Female Infertility Caused by Mutations in the Oocyte-Specific Translational Repressor PATL2.

Sateesh Maddirevula, Serdar Coskun, Saad Alhassan, Atif Elnour, Hessa S. Alsaif, Niema Ibrahim, Firdous Abdulwahab, Stefan T. Arold, Fowzan S Alkuraya 

American Journal of Human Genetics

Autozygosity reveals recessive mutations and novel mechanisms in dominant genes: implications in variant interpretation.

Monies D, Maddirevula S, Kurdi W, Alanazi M, Al Khalidi H, Al-Owain M, Sulaiman RA, Faqeih E, Goljan E, Ibrahim N, Abdulwahab F, Hashem M, Abouelhoda M, Shaheen R, Arold ST, Alkuraya FS 

Genetics in Medicine  

The genome of Chenopodium quinoa.

Jarvis DE, Ho YS, Lightfoot DJ, Schmöckel SM, Li B, Borm TJ, Ohyanagi H, Mineta K, Michell CT, Saber N, Kharbatia NM, Rupper RR, Sharp AR, Dally N, Boughton BA, Woo YH, Gao G, Schijlen EG, Guo X, Momin AA, Negrão S, Al-Babili S, Gehring C, Roessner U, Jung C, Murphy K, Arold ST, Gojobori T, Linden CG, van Loo EN, Jellen EN, Maughan PJ, Tester M.

Nature 307-312

In silico screening for candidate chassis strains for free fatty acid-producing cyanobacteria.

Olaa Motwalli, Magbubah Essack, Boris R Jankovic, Boyang Ji, Xinyao Liu, Hifzur Rahman Ansari, Robert Hoehndorf, Xin Gao, Stefan T Arold, Katsuhiko Mineta, John A C Archer, Takashi Gojobori, Ivan Mijakovic, Vladimir B Bajic

BMC Genomics 18

KDF1, encoding keratinocyte differentiation factor 1, is mutated in a multigenerational family with ectodermal dysplasia.

Hanan E Shamseldin, Ola Khalifa, Yousef M Binamer, Abdulmonem Almutawa, Stefan T Arold, Hamad Zaidan, Fowzan S Alkuraya

Hum Genet 136, 99 - 105

Pre-mRNA splicing repression triggers abiotic stress signaling in plants.

Yu Ling, Sahar Alshareef, Haroon Butt, Jorge Lozano-Juste, Lixin Li, Aya A Galal, Ahmed Moustafa, Afaque Ahmad Momin, Manal Tashkandi, Dale N Richardson, Hiroaki Fujii, Stefan Arold, Pedro L Rodriguez, Paula Duque, Magdy M Mahfouz

Plant J

Clinical genomics expands the morbid genome of intellectual disability and offers a high diagnostic yield.

S Anazi, S Maddirevula, E Faqeih, H Alsedairy, F Alzahrani, H E Shamseldin, N Patel, M Hashem, N Ibrahim, F Abdulwahab, N Ewida, H S Alsaif, H Al Sharif, W Alamoudi, A Kentab, F A Bashiri, M Alnaser, A H AlWadei, M Alfadhel, W Eyaid, A Hashem, A Al Asmari, M M Saleh, A AlSaman, K A Alhasan, M Alsughayir, M Al Shammari, A Mahmoud, Z N Al-Hassnan, M Al-Husain, R Osama Khalil, N Abd El Meguid, A Masri, R Ali, T Ben-Omran, P El Fishway, A Hashish, A Ercan Sencicek, M State, A M Alazami, M A Salih, N Altassan, S T Arold, M Abouelhoda, S M Wakil, D Monies, R Shaheen, F S Alkuraya

Mol Psychiatry

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2016

ContaMiner and ContaBase: a webserver and database for early identification of unwantedly crystallized protein contaminants.

Arnaud Hungler, Afaque Momin, Kay Diederichs, Stefan T Arold

J Appl Crystallogr 49, 2252-2258

Mutation in SLC6A9 encoding a glycine transporter causes a novel form of non-ketotic hyperglycinemia in humans.

Majid Alfadhel, Marwan Nashabat, Hanan Al Qahtani, Ahmed Alfares, Fuad Al Mutairi, Hesham Al Shaalan, Ganka V Douglas, Klaas Wierenga, Jane Juusola, Muhammad Talal Alrifai, Stefan T Arold, Fowzan Alkuraya, Qais Abu Ali

Hum Genet

Crystal Structure of PKG I:cGMP Complex Reveals a cGMP-Mediated Dimeric Interface that Facilitates cGMP-Induced Activation.

Jeong Joo Kim, Robin Lorenz, Stefan T Arold, Albert S Reger, Banumathi Sankaran, Darren E Casteel, Friedrich W Herberg, Choel Kim

Structure 24, 710-20

Anti-apoptotic ARC protein confers chemoresistance by controlling leukemia-microenvironment interactions through a NFκB/IL1β signaling network.

Bing Z Carter, Po Yee Mak, Ye Chen, Duncan H Mak, Hong Mu, Rodrigo Jacamo, Vivian Ruvolo, Stefan T Arold, John E Ladbury, Jared K Burks, Steven Kornblau, Michael Andreeff

Oncotarget 7, 20054-67.

Truncating PREX2 mutations activate its GEF activity and alter gene expression regulation in NRAS-mutant melanoma.

Yonathan Lissanu Deribe, Yanxia Shi, Kunal Rai, Luigi Nezi, Samir B Amin, Chia-Chin Wu, Kadir C Akdemir, Mozhdeh Mahdavi, Qian Peng, Qing Edward Chang, Kirsti Hornigold, Stefan T Arold, Heidi C E Welch, Levi A Garraway, Lynda Chin

Proc Natl Acad Sci U S A

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2015

MLLT1 YEATS domain mutations in clinically distinctive Favourable Histology Wilms tumours.

Elizabeth J Perlman, Samantha Gadd, Stefan T Arold, Anand Radhakrishnan, Daniela S Gerhard, Lawrence Jennings, Vicki Huff, Jaime M Guidry Auvil, Tanja M Davidsen, Jeffrey S Dome, Daoud Meerzaman, Chih Hao Hsu, Cu Nguyen, James Anderson, Yussanne Ma, Andrew J Mungall, Richard A Moore, Marco A Marra, Charles G Mullighan, Jing Ma, David A Wheeler, Oliver A Hampton, Julie M Gastier-Foster, Nicole Ross, Malcolm A Smith

Nat Commun 6

PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response.

Hsin-Wei Liao, Jung-Mao Hsu, Weiya Xia, Hung-Ling Wang, Ying-Nai Wang, Wei-Chao Chang, Stefan T Arold, Chao-Kai Chou, Pei-Hsiang Tsou, Hirohito Yamaguchi, Yueh-Fu Fang, Hong-Jen Lee, Heng-Huan Lee, Shyh-Kuan Tai, Mhu-Hwa Yang, Maria P Morelli, Malabika Sen, John E Ladbury, Chung-Hsuan Chen, Jennifer R Grandis, Scott Kopetz, Mien-Chie Hung

J Clin Invest 125, 4529 - 43

Beyond initiation-limited translational bursting: the effects of burst size distributions on the stability of gene expression.

Hiroyuki Kuwahara, Stefan T Arold, Xin Gao

Integr Biol (Camb) 7, 1622 - 32

An integrated structure- and system-based framework to identify new targets of metabolites and known drugs.

Hammad Naveed, Umar S Hameed, Deborah Harrus, William Bourguet, Stefan T Arold, Xin Gao

Bioinformatics 31, 3922 - 9

Regulation of the PI3K pathway through a p85α monomer-homodimer equilibrium.

Lydia W T Cheung, Katarzyna W Walkiewicz, Tabot M D Besong, Huifang Guo, David H Hawke, Stefan T Arold, Gordon B Mills

Elife 4

A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress.

Joan Ritho, Stefan T Arold, Edward T H Yeh

Cell Rep 12, 734 - 42

T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26.

Stephan Meller, Jeremy Di Domizio, Kui S Voo, Heike C Friedrich, Georgios Chamilos, Dipyaman Ganguly, Curdin Conrad, Josh Gregorio, Didier Le Roy, Thierry Roger, John E Ladbury, Bernhard Homey, Stanley Watowich, Robert L Modlin, Dimitrios P Kontoyiannis, Yong-Jun Liu, Stefan T Arold, Michel Gilliet

Nat Immunol 16, 970 - 9

How to awaken your nanomachines: Site-specific activation of focal adhesion kinases through ligand interactions.

Katarzyna W Walkiewicz, Jean-Antoine Girault, Stefan T Arold

Prog Biophys Mol Biol 119, 60 - 71

HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer.

Delphine R Boulbes, Stefan T Arold, Gaurav B Chauhan, Korina V Blachno, Nanfu Deng, Wei-Chao Chang, Quanri Jin, Tzu-Hsuan Huang, Jung-Mao Hsu, Samuel W Brady, Chandra Bartholomeusz, John E Ladbury, Steve Stone, Dihua Yu, Mien-Chie Hung, Francisco J Esteva

Mol Oncol 9, 586 - 600

Conformational dynamics of the focal adhesion targeting domain control specific functions of focal adhesion kinase in cells.

Gress Kadare, Nicolas Gervasi, Karen Brami-Cherrier, Heike Blockus, Said El Messari, Stefan T Arold, Jean-Antoine Girault

J Biol Chem 290, 478 - 91

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2014

Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

David S Guttery, Benoit Poulin, Abhinay Ramaprasad, Richard J Wall, David J P Ferguson, Declan Brady, Eva-Maria Patzewitz, Sarah Whipple, Ursula Straschil, Megan H Wright, Alyaa M A H Mohamed, Anand Radhakrishnan, Stefan T Arold, Edward W Tate, Anthony A Holder, Bill Wickstead, Arnab Pain, Rita Tewari

Cell Host Microbe 16, 128 - 40

How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine-aspartic acid (LD) motifs.

Tanvir Alam, Meshari Alazmi, Xin Gao, Stefan T Arold

Biochem J 460, 317 - 29

FAK dimerization controls its kinase-dependent functions at focal adhesions.

Karen Brami-Cherrier, Nicolas Gervasi, Diana Arsenieva, Katarzyna Walkiewicz, Marie-Claude Boutterin, Alvaro Ortega, Paul G Leonard, Bastien Seantier, Laila Gasmi, Tahar Bouceba, Gress Kadare, Jean-Antoine Girault, Stefan T Arold

EMBO J 33, 356 - 70

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2013

A Biochemical/Biophysical Assay Dyad for HTS-Compatible Triaging of Inhibitors of the HIV-1 Nef/Hck SH3 Interaction.

Sebastian Breuer, Sheryll Espinola, Xavier Morelli, Bruce E Torbett, Stefan T Arold, Ingo H Engels

Curr Chem Genom Transl Med 7, 16 - 20

Findings from the Peutz-Jeghers syndrome registry of uruguay.

Asadur Tchekmedyian, Christopher I Amos, Sherri J Bale, Dakai Zhu, Stefan Arold, Joaquin Berrueta, Natalie Nabon, Thomas McGarrity

PLoS One 8

Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli.

Kin Man Suen, Chi-Chuan Lin, Roger George, Fernando A Melo, Eleanor R Biggs, Zamal Ahmed, Melanie N Drake, Swathi Arur, Stefan T Arold, John E Ladbury

Nat Struct Mol Biol 20, 620 - 7

Increased activity of the vesicular soluble N-ethylmaleimide-sensitive factor attachment protein receptor TI-VAMP/VAMP7 by tyrosine phosphorylation in the Longin domain.

Andrea Burgo, Alessandra M Casano, Aurelia Kuster, Stefan T Arold, Guan Wang, Sebastien Nola, Agathe Verraes, Florent Dingli, Damarys Loew, Thierry Galli

J Biol Chem 288, 11960 - 72

Solution structure of the tandem acyl carrier protein domains from a polyunsaturated fatty acid synthase reveals beads-on-a-string configuration.

Uldaeliz Trujillo, Edwin Vazquez-Rosa, Delise Oyola-Robles, Loren J Stagg, David A Vassallo, Irving E Vega, Stefan T Arold, Abel Baerga-Ortiz

PLoS One 8

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2012

A noncanonical mu-1A-binding motif in the N terminus of HIV-1 Nef determines its ability to downregulate major histocompatibility complex class I in T lymphocytes.

Sayuki Iijima, Young-Jung Lee, Hirotaka Ode, Stefan T Arold, Nobuyuki Kimura, Masaru Yokoyama, Hironori Sato, Yasuhito Tanaka, Klaus Strebel, Hirofumi Akari

J Virol 86, 3944 - 51

Noise in cellular signaling pathways: causes and effects.

John E Ladbury, Stefan T Arold

Trends Biochem Sci 37, 173 - 8

Structural recognition mechanisms between human Src homology domain 3 (SH3) and ALG-2-interacting protein X (Alix).

Xiaoli Shi, Stephane Betzi, Adrien Lugari, Sandrine Opi, Audrey Restouin, Isabelle Parrot, Jean Martinez, Pascale Zimmermann, Patrick Lecine, Mingdong Huang, Stefan T Arold, Yves Collette, Xavier Morelli

FEBS Lett 586, 1759 - 64

Catalytic protein modification with dirhodium metallopeptides: specificity in designed and natural systems.

Zhen Chen, Farrukh Vohidov, Jane M Coughlin, Loren J Stagg, Stefan T Arold, John E Ladbury, Zachary T Ball

J Am Chem Soc 134, 10138 - 45

Inhibition of basal FGF receptor signaling by dimeric Grb2.

Chi-Chuan Lin, Fernando A Melo, Ragini Ghosh, Kin M Suen, Loren J Stagg, John Kirkpatrick, Stefan T Arold, Zamal Ahmed, John E Ladbury

Cell 149, 1514 - 24

A landscape of driver mutations in melanoma.

Eran Hodis, Ian R Watson, Gregory V Kryukov, Stefan T Arold, Marcin Imielinski, Jean-Philippe Theurillat, Elizabeth Nickerson, Daniel Auclair, Liren Li, Chelsea Place, Daniel Dicara, Alex H Ramos, Michael S Lawrence, Kristian Cibulskis, Andrey Sivachenko, Douglas Voet, Gordon Saksena, Nicolas Stransky, Robert C Onofrio, Wendy Winckler, Kristin Ardlie, Nikhil Wagle, Jennifer Wargo, Kelly Chong, Donald L Morton, Katherine Stemke-Hale, Guo Chen, Michael Noble, Matthew Meyerson, John E Ladbury, Michael A Davies, Jeffrey E Gershenwald, Stephan N Wagner, Dave S B Hoon, Dirk Schadendorf, Eric S Lander, Stacey B Gabriel, Gad Getz, Levi A Garraway, Lynda Chin

Cell 150, 251 - 63

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2011

A specific protein disorder catalyzer of HIV-1 Nef.

Adrien Lugari, Sebastian Breuer, Thibault Coursindel, Sandrine Opi, Audrey Restouin, Xiaoli Shi, Alexis Nazabal, Bruce E Torbett, Jean Martinez, Yves Collette, Isabelle Parrot, Stefan T Arold, Xavier Morelli

Bioorg Med Chem 19, 7401 - 6

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action.

Stefan T Arold

Curr Opin Struct Biol 21, 808 - 13

Energetics of Src homology domain interactions in receptor tyrosine kinase-mediated signaling.

John E Ladbury, Stefan T Arold

Methods Enzymol 488, 147 - 83

Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.

Nam Ky Tonthat, Stefan T Arold, Brian F Pickering, Michael W Van Dyke, Shoudan Liang, Yue Lu, Tushar K Beuria, William Margolin, Maria A Schumacher

EMBO J 30, 154 - 64

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2010

Phosphatidylinositol 4,5-bisphosphate-induced conformational change of ezrin and formation of ezrin oligomers.

Kevin Carvalho, Nada Khalifat, Ofelia Maniti, Claire Nicolas, Stefan Arold, Catherine Picart, Laurence Ramos

Biochemistry 49, 9318 - 27

H-NS forms a superhelical protein scaffold for DNA condensation.

Stefan T Arold, Paul G Leonard, Gary N Parkinson, John E Ladbury

Proc Natl Acad Sci U S A 107, 15728 - 32

Identification and biophysical assessment of the molecular recognition mechanisms between the human haemopoietic cell kinase Src homology domain 3 and ALG-2-interacting protein X.

Xiaoli Shi, Sandrine Opi, Adrien Lugari, Audrey Restouin, Thibault Coursindel, Isabelle Parrot, Javier Perez, Eric Madore, Pascale Zimmermann, Jacques Corbeil, Mingdong Huang, Stefan T Arold, Yves Collette, Xavier Morelli

Biochem J 431, 93 - 102

Phosphatidylinositol-(4,5)-bisphosphate enables efficient secretion of HIV-1 Tat by infected T-cells.

Fabienne Rayne, Solene Debaisieux, Hocine Yezid, Yea-Lih Lin, Clement Mettling, Karidia Konate, Nathalie Chazal, Stefan T Arold, Martine Pugniere, Francoise Sanchez, Anne Bonhoure, Laurence Briant, Erwann Loret, Christian Roy, Bruno Beaumelle

EMBO J 29, 1348 - 62

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2009

Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance.

Marie-Line Garron, Diana Arsenieva, Jessie Zhong, Alexander B Bloom, Adam Lerner, Geraldine M O'Neill, Stefan T Arold

J Mol Biol 386, 190 - 203

Alternative splicing modulates autoinhibition and SH3 accessibility in the Src kinase Fyn.

C Brignatz, M P Paronetto, S Opi, M Cappellari, S Audebert, V Feuillet, G Bismuth, S Roche, S T Arold, C Sette, Y Collette

Mol Cell Biol 29, 6438 - 48

The TCL1A oncoprotein interacts directly with the NF-kappaB inhibitor IkappaB.

Virginie Ropars, Gilles Despouy, Marc-Henri Stern, Serge Benichou, Christian Roumestand, Stefan T Arold

PLoS One 4

ROP2 from Toxoplasma gondii: a virulence factor with a protein-kinase fold and no enzymatic activity.

Gilles Labesse, Muriel Gelin, Yannick Bessin, Maryse Lebrun, Julien Papoin, Rachel Cerdan, Stefan T Arold, Jean-Francois Dubremetz

Structure 17, 139 - 46

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2008

Nuclear localization of cytoplasmic poly(A)-binding protein upon rotavirus infection involves the interaction of NSP3 with eIF4G and RoXaN.

Maya Harb, Michelle M Becker, Damien Vitour, Carolina H Baron, Patrice Vende, Spencer C Brown, Susanne Bolte, Stefan T Arold, Didier Poncet

J Virol 82, 11283 - 93

Molecular basis for group-specific activation of the virulence regulator PlcR by PapR heptapeptides.

L Bouillaut, S Perchat, S Arold, S Zorrilla, L Slamti, C Henry, M Gohar, N Declerck, D Lereclus

Nucleic Acids Res 36, 3791 - 801

Molecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinase.

C Gondeau, L Chaloin, P Lallemand, B Roy, C Perigaud, T Barman, A Varga, M Vas, C Lionne, S T Arold

Nucleic Acids Res 36, 3620 - 9

Structural basis for the interaction between focal adhesion kinase and CD4.

Marie-Line Garron, James Arthos, Jean-Francois Guichou, Jonathan McNally, Claudia Cicala, Stefan T Arold

J Mol Biol 375, 1320 - 8

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2007

Protein protein interaction inhibition (2P2I) combining high throughput and virtual screening: Application to the HIV-1 Nef protein.

Stephane Betzi, Audrey Restouin, Sandrine Opi, Stefan T Arold, Isabelle Parrot, Francoise Guerlesquin, Xavier Morelli, Yves Collette

Proc Natl Acad Sci U S A 104, 19256 - 61

The solution structure of the adhesion protein Bd37 from Babesia divergens reveals structural homology with eukaryotic proteins involved in membrane trafficking.

Stephane Delbecq, Daniel Auguin, Yin-Shan Yang, Frank Lohr, Stefan Arold, Theo Schetters, Eric Precigout, Andre Gorenflot, Christian Roumestand

J Mol Biol 375, 409 - 24

Structure of PlcR: Insights into virulence regulation and evolution of quorum sensing in Gram-positive bacteria.

Nathalie Declerck, Laurent Bouillaut, Denis Chaix, Nathalie Rugani, Leyla Slamti, Francois Hoh, Didier Lereclus, Stefan T Arold

Proc Natl Acad Sci U S A 104, 18490 - 5

NAD kinases use substrate-assisted catalysis for specific recognition of NAD.

Guillaume Poncet-Montange, Liliane Assairi, Stefan Arold, Sylvie Pochet, Gilles Labesse

J Biol Chem 282, 33925 - 34

GIT1 utilizes a focal adhesion targeting-homology domain to bind paxillin.

Robert Schmalzigaug, Marie-Line Garron, J Tyler Roseman, Yanghui Xing, Collin E Davidson, Stefan T Arold, Richard T Premont

Cell Signal 19, 1733 - 44

ROP18 is a rhoptry kinase controlling the intracellular proliferation of Toxoplasma gondii.

Hiba El Hajj, Maryse Lebrun, Stefan T Arold, Henri Vial, Gilles Labesse, Jean Francois Dubremetz

PLoS Pathog

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2004

Structural basis for the co-activation of protein kinase B by T-cell leukemia-1 (TCL1) family proto-oncoproteins.

Daniel Auguin, Philippe Barthe, Catherine Royer, Marc-Henri Stern, Masayuki Noguchi, Stefan T Arold, Christian Roumestand

J Biol Chem 279, 35890 - 902

A mutant impaired in SNARE complex dissociation identifies the plasma membrane as first target of synaptobrevin 2.

Sonia Martinez-Arca, Stefan Arold, Rachel Rudge, Fabrice Laroche, Thierry Galli

Traffic 5, 371 - 82

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2003

Crystal structure of the N-terminal dimerisation domain of VicH, the H-NS-like protein of Vibrio cholerae.

Rachel Cerdan, Vanessa Bloch, Yinshan Yang, Philippe Bertin, Christian Dumas, Sylvie Rimsky, Michel Kochoyan, Stefan T Arold

J Mol Biol 334, 179 - 85

Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain.

Maria K Hoellerer, Martin E M Noble, Gilles Labesse, Iain D Campbell, Jorn M Werner, Stefan T Arold

Structure 11, 1207 - 17

The H-NS dimerization domain defines a new fold contributing to DNA recognition.

Vanessa Bloch, Yinshan Yang, Emmanuel Margeat, Alain Chavanieu, Marie Therese Auge, Bruno Robert, Stefan Arold, Sylvie Rimsky, Michel Kochoyan

Nat Struct Biol 10, 212 - 8

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2002

The structural basis of localization and signaling by the focal adhesion targeting domain.

Stefan T Arold, Maria K Hoellerer, Martin E M Noble

Structure 10, 319 - 27

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2001

Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.

P D'Aloja, A C Santarcangelo, S Arold, A Baur, M Federico

J Gen Virol 82, 2735 - 45

Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.

S T Arold, A S Baur

Trends Biochem Sci 26, 356 - 63

The role of the Src homology 3-Src homology 2 interface in the regulation of Src kinases.

S T Arold, T S Ulmer, T D Mulhern, J M Werner, J E Ladbury, I D Campbell, M E Noble

J Biol Chem 276, 17199 - 205

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2000

Characterization and molecular basis of the oligomeric structure of HIV-1 nef protein.

S Arold, F Hoh, S Domergue, C Birck, M A Delsuc, M Jullien, C Dumas

Protein Sci 9, 1137 - 48

Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions.

L X Liu, N Heveker, O T Fackler, S Arold, S Le Gall, K Janvier, B M Peterlin, C Dumas, O Schwartz, S Benichou, R Benarous

J Virol 74, 5310 - 9

Nef-induced major histocompatibility complex class I down-regulation is functionally dissociated from its virion incorporation, enhancement of viral infectivity, and CD4 down-regulation.

H Akari, S Arold, T Fukumori, T Okazaki, K Strebel, A Adachi

J Virol 74, 2907 - 12

Searching for specificity in SH domains.

J E Ladbury, S Arold

Chem Biol 7

HIV-2 and SIV nef proteins target different Src family SH3 domains than does HIV-1 Nef because of a triple amino acid substitution.

Y Collette, S Arold, C Picard, K Janvier, S Benichou, R Benarous, D Olive, C Dumas

J Biol Chem 275, 4171 - 6

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1998

RT loop flexibility enhances the specificity of Src family SH3 domains for HIV-1 Nef.

S Arold, R O'Brien, P Franken, M P Strub, F Hoh, C Dumas, J E Ladbury

Biochemistry 37, 14683 - 91

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1997

The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling.

S Arold, P Franken, M P Strub, F Hoh, S Benichou, R Benarous, C Dumas

Structure 5, 1361 - 72

HIV-1 Nef protein: purification, crystallizations, and preliminary X-ray diffraction studies.

P Franken, S Arold, A Padilla, M Bodeus, F Hoh, M P Strub, M Boyer, M Jullien, R Benarous, C Dumas

Protein Sci 6, 2681 - 3

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